EDUCATION

Ph.D.  Adenovirus-mediated gene transfer (Virology), 2007, Université de Lyon (UCBLyonI), France
M.S.Biochemistry (Option: Microbiology), 1987, Université Aix-Marseille I, France
CES. Immunology, 1988, Université Aix-Marseille II, France
BTS. Biochemistry, 1984, LTE M.Curie Marseille, France

RESEARCH INTERESTS

Horizontal Gene Transfer, Recombination, Virology
Since I have joigned the GME lab, 1 and half year ago, I work on the development of an innovative tool for metagenomics called “Genefish” (a specific strain devoted to gene capture).
This project is involved in the European Project METAEXPLORE

PUBLICATIONS

Protein crystals in Adenovirus type 5-infected cells: requirements for intranuclear crystallogenesis, structural and functional analysis.
Franqueville L, Henning P, Magnusson M, Vigne E, Schoehn G, Blair-Zajdel ME, Habib N, Lindholm L, Blair GE, Hong SS, Boulanger P.PLoS One. 2008 Aug 6;3(8):e2894.

Toxicity of fiber- and penton base-modified adenovirus type 5 vectors on lung development in newborn rats.
Waszak P, Franqueville L, Franco-Motoya ML, Rosa-Calatrava M, Boucherat O, Lindholm L, Delacourt C, Boulanger P.Mol Ther. 2007 Nov;15(11):2008-16. Epub 2007 Jul 24.

Adenovirus type 5 fiber knob domain has a critical role in fiber protein synthesis and encapsidation.
Henning P, Lundgren E, Carlsson M, Frykholm K, Johannisson J, Magnusson MK, Tång E, Franqueville L, Hong SS, Lindholm L, Boulanger P.J Gen Virol. 2006 Nov;87(Pt 11):3151-60.

Enhancement of adenovirus-mediated gene delivery to rheumatoid arthritis synoviocytes and synovium by fiber modifications: role of arginine-glycine-aspartic acid (RGD)- and non-RGD-binding integrins.
Toh ML, Hong SS, van de Loo F, Franqueville L, Lindholm L, van den Berg W, Boulanger P, Miossec P.J Immunol. 2005 Dec 1;175(11):7687-98.

The 100K-chaperone protein from adenovirus serotype 2 (Subgroup C) assists in trimerization and nuclear localization of hexons from subgroups C and B adenoviruses.
Hong SS, Szolajska E, Schoehn G, Franqueville L, Myhre S, Lindholm L, Ruigrok RW, Boulanger P, Chroboczek J.J Mol Biol. 2005 Sep 9;352(1):125-38.

Gene transduction and cell entry pathway of fiber-modified adenovirus type 5 vectors carrying novel endocytic peptide ligands selected on human tracheal glandular cells. Gaden F, Franqueville L, Magnusson MK, Hong SS, Merten MD, Lindholm L, Boulanger P. J Virol. 2004 Jul;78(13):7227-47.
Mitogenic activity of Epstein-Barr virus-encoded BARF1 protein.
Sall A, Caserta S, Jolicoeur P, Franqueville L, de Turenne-Tessier M, Ooka T. Oncogene. 2004 Jun 17;23(28):4938-44.

Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5.
Salone B, Martina Y, Piersanti S, Cundari E, Cherubini G, Franqueville L, Failla CM, Boulanger P, Saggio I. J Virol. 2003 Dec;77(24):13448-54.

Identification of adenovirus (ad) penton base neutralizing epitopes by use of sera from patients who had received conditionally replicative ad (addl1520) for treatment of liver tumors.
Hong SS, Habib NA, Franqueville L, Jensen S, Boulanger PA. J Virol. 2003 Oct;77(19):10366-75.

Mechanism of restriction of normal and cystic fibrosis transmembrane conductance regulator-deficient human tracheal gland cells to adenovirus infection and ad-mediated gene transfer.
Gaden F, Franqueville L, Hong SS, Legrand V, Figarella C, Boulanger P. Am J Respir Cell Mol Biol. 2002 Nov;27(5):628-40.

Posters in MGE lab:

Genefish : an alternate metagenomic approach for capturing targeted bacterial diversity in an engineered recipient E. coli strain
N.Lombard, A.Faugier, C.Lavire, S.Jacquiod, L.Philippot, X.Zhang, J.C.Lazzaroni, P.Simonet and L.Franqueville. (2009) 10th symposium on bacterial genetics and ecology (BAGECO-10), Uppsala, Sweden.

CURRICULUM VITAE

Click here for pdf of CV in French

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