Origin of Dehalogenases and De Novo Dehalogenase Gene Synthesis
While our research twenty years ago dealt with the biodegradation of chlorinated compounds, the capability of bacteria to degrade these compounds is no longer in question. Our work has evolved towards trying to understand where and how this degradative capacity arises. Several model compounds have been used such as lindane, which is the gamma isomer of hexachlorocyclohexane, and tetra- and tri-chloroethylene (PCE and TCE), polychlorinated biphenyls (PCBs) and now Chlordecone. Today, we are exploring the genetic resources available and necessary for the adaptation (e.g., the development of a metabolic pathway) to chlorinated compounds. Part of this work is related to analyzing microbial communities stressed by these compounds and part is through the laboratory synthesis of the appropriate genes from non-polluted metagenomic DNA. In addition, metagenomic, metatranscriptomic and metaproteomic approaches are being applied to understand the importance of teh microbial community on dechloriantion. This basic knowledge is also applied to the clean-up of polluted sites and a video gives a hint about how.
Evasol Axelera Biodechlor
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